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Top 23 Python Agent Projects
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ragflow
RAGFlow is a leading open-source Retrieval-Augmented Generation (RAG) engine that fuses cutting-edge RAG with Agent capabilities to create a superior context layer for LLMs
Project mention: The AI-Native GraphDB + GraphRAG + Graph Memory Landscape & Market Catalog | dev.to | 2025-10-26 -
InfluxDB
InfluxDB – Built for High-Performance Time Series Workloads. InfluxDB 3 OSS is now GA. Transform, enrich, and act on time series data directly in the database. Automate critical tasks and eliminate the need to move data externally. Download now.
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The OpenHands CLI has had some major improvements since v1: https://github.com/OpenHands/OpenHands
MIT license and model agnostic
I’d also keep a close eye on Toad which is launching soon
- Project mention: Llama-Factory: Unified, Efficient Fine-Tuning for 100 Open LLMs | news.ycombinator.com | 2025-09-18
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MetaGPT
🌟 The Multi-Agent Framework: First AI Software Company, Towards Natural Language Programming
Project mention: Backlog.md – CLI that auto-generates task files (took my Claude success to 95 %) | news.ycombinator.com | 2025-07-06 -
unsloth
Fine-tuning & Reinforcement Learning for LLMs. 🦥 Train OpenAI gpt-oss, DeepSeek-R1, Qwen3, Gemma 3, TTS 2x faster with 70% less VRAM.
Project mention: Unsloth – Train LLMs 2x faster with 70% less VRAM | news.ycombinator.com | 2025-12-10 -
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Stream
Stream - Scalable APIs for Chat, Feeds, Moderation, & Video. Stream helps developers build engaging apps that scale to millions with performant and flexible Chat, Feeds, Moderation, and Video APIs and SDKs powered by a global edge network and enterprise-grade infrastructure.
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khoj
Your AI second brain. Self-hostable. Get answers from the web or your docs. Build custom agents, schedule automations, do deep research. Turn any online or local LLM into your personal, autonomous AI (gpt, claude, gemini, llama, qwen, mistral). Get started - free.
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Jobs_Applier_AI_Agent_AIHawk
AIHawk aims to easy job hunt process by automating the job application process. Utilizing artificial intelligence, it enables users to apply for multiple jobs in a tailored way.
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gpt-researcher
An LLM agent that conducts deep research (local and web) on any given topic and generates a long report with citations.
For demonstration purposes, I'll be using the gpt-researcher tool. Github link: https://github.com/assafelovic/gpt-researcher
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vanna
🤖 Chat with your SQL database 📊. Accurate Text-to-SQL Generation via LLMs using Agentic Retrieval 🔄.
Project mention: How to Use Vanna.ai to Query Your Database with Open-Source Language Models | dev.to | 2025-12-02Vanna.ai GitHub: https://github.com/vanna-ai/vanna
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deer-flow
DeerFlow is a community-driven Deep Research framework, combining language models with tools like web search, crawling, and Python execution, while contributing back to the open-source community.
View the Project on GitHub
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SWE-agent
SWE-agent takes a GitHub issue and tries to automatically fix it, using your LM of choice. It can also be employed for offensive cybersecurity or competitive coding challenges. [NeurIPS 2024]
Project mention: Boost Your Coding Agent and Understand Its Reasoning with 3 Simple Prompts | dev.to | 2025-06-20SWE-Agent
- Project mention: Tongyi DeepResearch – open-source 30B MoE Model that rivals OpenAI DeepResearch | news.ycombinator.com | 2025-11-02
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serena
A powerful coding agent toolkit providing semantic retrieval and editing capabilities (MCP server & other integrations)
Project mention: Building a 400K-Line Full-Stack App Solo with Claude Code in 2025 | dev.to | 2025-12-22Serena - Semantic code search and editing tool
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camel
🐫 CAMEL: The first and the best multi-agent framework. Finding the Scaling Law of Agents. https://www.camel-ai.org
[Enhance] tokenlimit Summarize up to the Last User Message · Issue #3371 · camel-ai/camel
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GitHub Link: https://github.com/agentscope-ai/agentscope Summary: Agentscope is an agent-oriented programming library that makes it easier to build LLM applications. It's designed to be "developer-centric" with features like asynchronous execution, parallel tool calls, and real-time steering. It offers a transparent approach where prompt engineering and API invocation are fully visible and controllable. Why it's important: Agentscope, along with its related libraries like agentscope-runtime and agentscope-studio, provides a comprehensive toolkit for not only developing but also deploying and visualizing agent-based applications.
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AstrBot
✨ Agentic IM ChatBot Infrastructure — 聊天智能体基础设施 ✨ 多消息平台集成（QQ / Telegram / 企微 / 飞书 / 钉钉等），强大易用的插件系统，支持 OpenAI / Gemini / Anthropic / Dify / Coze / 阿里云百炼 / 知识库 / Agent 智能体
Project mention: AstrBot: Revolutionizing Chatbot Development with Ease and Flexibility | dev.to | 2025-03-26View the Project on GitHub
- Project mention: OSS Alternative to Open WebUI – ChatGPT-Like UI, API and CLI | news.ycombinator.com | 2025-11-03
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Link: https://github.com/GibsonAI/Memori
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RD-Agent
Research and development (R&D) is crucial for the enhancement of industrial productivity, especially in the AI era, where the core aspects of R&D are mainly focused on data and models. We are committed to automating these high-value generic R&D processes through R&D-Agent, which lets AI drive data-driven AI. 🔗https://aka.ms/RD-Agent-Tech-Report
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Microsoft's agent-lightning project offers a comprehensive toolkit aimed at accelerating the process of building, testing, and deploying AI Agents. This open-source initiative highlights the industry's commitment to enabling faster development and implementation of advanced AI capabilities, providing developers with robust resources to streamline AI agent creation.
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SaaSHub
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NOTE: The open source projects on this list are ordered by number of github stars. The number of mentions indicates repo mentiontions in the last 12 Months or since we started tracking (Dec 2020).
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How to Use Vanna.ai to Query Your Database with Open-Source Language Models
- A note from our sponsor - SaaSHub www.saashub.com | 22 Dec 2025
Index
What are some of the best open-source Agent projects in Python? This list will help you:
| # | Project | Stars |
|---|---|---|
| 1 | ragflow | 70,257 |
| 2 | OpenHands | 65,761 |
| 3 | LLaMA-Factory | 64,310 |
| 4 | MetaGPT | 60,954 |
| 5 | unsloth | 49,610 |
| 6 | mem0 | 44,522 |
| 7 | ChatTTS | 38,345 |
| 8 | khoj | 31,962 |
| 9 | Jobs_Applier_AI_Agent_AIHawk | 29,188 |
| 10 | gpt-researcher | 24,570 |
| 11 | vanna | 21,958 |
| 12 | deer-flow | 18,761 |
| 13 | SWE-agent | 18,024 |
| 14 | DeepResearch | 17,631 |
| 15 | serena | 17,340 |
| 16 | camel | 15,069 |
| 17 | agentscope | 14,542 |
| 18 | AstrBot | 14,197 |
| 19 | agent-zero | 12,620 |
| 20 | Memori | 11,119 |
| 21 | RD-Agent | 9,845 |
| 22 | agent-lightning | 9,794 |
| 23 | UFO | 7,821 |
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