It looks like the PR #78 wrapping of the apache httpd daemon in a minimal service scritp to allow clean restarts e.g. on certificate renewal added the side effect that the environment inside apache subprocesses from CGI and WSGI lack a complete PATH setting. In particular the binaries in the previously available /usr/local/bin/ folder are no longer found.

As a workaround the binaries can be installed or linked into e.g. /user/bin/, but it would probably be better to restore the previous environment where /usr/local/bin/ is a part of the default search PATH.