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I got it working, IIRC, I followed this guide and added the following:

environment.systemPackages = [ pkgs.uv ] programs.nix-ld = { enable = true; libraries = [ config.boot.kernelPackages.nvidia_x11 ]; } 

My nvidia config:

 hardware = { graphics.enable = true; nvidia = { nvidiaSettings = true; open = true; }; }; 

I looked at this comfyui issue, then downloaded comfyui and ran these commands in the directory: uv add --requirements requirements.txt, uv sync --extra cu126.

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@Oneechan69
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@edwardsdigital
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