If you are configuring to monitor a remote host, you will have to add a command in your nrpe.cfg found at /usr/local/nagios/etc/.
This command should be on the remote host. The sample commands that are already defined are :
/usr/local/nagios/libexec/check_nrpe -H localhost -c check_users /usr/local/nagios/libexec/check_nrpe -H localhost -c check_load /usr/local/nagios/libexec/check_nrpe -H localhost -c check_hda1 /usr/local/nagios/libexec/check_nrpe -H localhost -c check_total_procs /usr/local/nagios/libexec/check_nrpe -H localhost -c check_zombie_procs
Then adding the command definition to the any of the config file that you have specified in nagios.cfg
define command{ command_name check_nrpe command_line $USER1$/check_nrpe -H $HOSTADDRESS$ -c $ARG1$ }
And finally your host and service
Correct me if i am wrong. I am not sure if nagios would reset the settings back to default for commands.cfg.