TL;DR
env LDFLAGS="-I/usr/local/opt/openssl/include -L/usr/local/opt/openssl/lib" pip install psycopg2 # OR env LDFLAGS="-I/usr/local/opt/openssl@3/include -L/usr/local/opt/openssl@3/lib" pip install psycopg2 # OR # https://github.com/brianmario/mysql2/issues/795#issuecomment-337006164 env LIBRARY_PATH="/usr/local/opt/openssl@3/lib" pip install psycopg2 --no-cache
The reason is that probably it might work faster in my machine if it was installed using the not binary version
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