I tried something like this:
route add -host 54.81.143.201 -interface en0
for the above thanks to https://superuser.com/a/756146/1006908 it doesn't solve the problem I just need port 70 (tcp) to be on interface en0, but it makes everything on it.
Workaround:
If I add the route, connect to Wireguard, then remove the route everything including ssh, and websites will work for me.
But it's obviously not sane.