We are running selenium tests against Chrome 46 on Selenium grid and we got the below error frequently:

Exception in thread "main" org.openqa.selenium.WebDriverException: Error forwarding the new session Error forwarding the request Read timed out
Command duration or timeout: 662.06 seconds
Build info: version: '2.46.0', revision: '61506a4624b13675f24581e453592342b7485d71', time: '2015-06-04 10:22:50'
System info: host: 'IE00079760', ip: '192.168.56.1', os.name: 'Windows 7', os.arch: 'amd64', os.version: '6.1', java.version: '1.7.0_17'
Driver info: org.openqa.selenium.remote.RemoteWebDriver
at sun.reflect.NativeConstructorAccessorImpl.newInstance0(Native Method)
at sun.reflect.NativeConstructorAccessorImpl.newInstance(NativeConstructorAccessorImpl.java:57)
at sun.reflect.DelegatingConstructorAccessorImpl.newInstance(DelegatingConstructorAccessorImpl.java:45)
at java.lang.reflect.Constructor.newInstance(Constructor.java:525)
at org.openqa.selenium.remote.ErrorHandler.createThrowable(ErrorHandler.java:204)
at org.openqa.selenium.remote.ErrorHandler.throwIfResponseFailed(ErrorHandler.java:156)
at org.openqa.selenium.remote.RemoteWebDriver.execute(RemoteWebDriver.java:605)
at org.openqa.selenium.remote.RemoteWebDriver.startSession(RemoteWebDriver.java:242)
at org.openqa.selenium.remote.RemoteWebDriver.(RemoteWebDriver.java:128)
at org.openqa.selenium.remote.RemoteWebDriver.(RemoteWebDriver.java:155)
at webdriver.WebdriverExample.main(WebdriverExample.java:69)
Caused by: org.openqa.selenium.WebDriverException: Error forwarding the new session Error forwarding the request Read timed out
Build info: version: '2.46.0', revision: '61506a4624b13675f24581e453592342b7485d71', time: '2015-06-04 10:22:50'
System info: host: 'IE00079760', ip: '192.168.56.1', os.name: 'Windows 7', os.arch: 'amd64', os.version: '6.1', java.version: '1.7.0_17'
Driver info: driver.version: unknown
at org.openqa.grid.web.servlet.handler.RequestHandler.process(RequestHandler.java:114)
at org.openqa.grid.web.servlet.DriverServlet.process(DriverServlet.java:83)
at org.openqa.grid.web.servlet.DriverServlet.doPost(DriverServlet.java:67)
at javax.servlet.http.HttpServlet.service(HttpServlet.java:727)
at javax.servlet.http.HttpServlet.service(HttpServlet.java:820)
at org.seleniumhq.jetty7.servlet.ServletHolder.handle(ServletHolder.java:565)
at org.seleniumhq.jetty7.servlet.ServletHandler.doHandle(ServletHandler.java:479)
at org.seleniumhq.jetty7.server.session.SessionHandler.doHandle(SessionHandler.java:225)
at org.seleniumhq.jetty7.server.handler.ContextHandler.doHandle(ContextHandler.java:1031)
at org.seleniumhq.jetty7.servlet.ServletHandler.doScope(ServletHandler.java:406)
at org.seleniumhq.jetty7.server.session.SessionHandler.doScope(SessionHandler.java:186)
at org.seleniumhq.jetty7.server.handler.ContextHandler.doScope(ContextHandler.java:965)
at org.seleniumhq.jetty7.server.handler.ScopedHandler.handle(ScopedHandler.java:117)
at org.seleniumhq.jetty7.server.handler.HandlerWrapper.handle(HandlerWrapper.java:111)
at org.seleniumhq.jetty7.server.Server.handle(Server.java:349)
at org.seleniumhq.jetty7.server.AbstractHttpConnection.handleRequest(AbstractHttpConnection.java:452)
at org.seleniumhq.jetty7.server.BlockingHttpConnection.handleRequest(BlockingHttpConnection.java:47)
at org.seleniumhq.jetty7.server.AbstractHttpConnection.content(AbstractHttpConnection.java:894)
at org.seleniumhq.jetty7.server.AbstractHttpConnection$RequestHandler.content(AbstractHttpConnection.java:948)
at org.seleniumhq.jetty7.http.HttpParser.parseNext(HttpParser.java:857)
at org.seleniumhq.jetty7.http.HttpParser.parseAvailable(HttpParser.java:235)
at org.seleniumhq.jetty7.server.BlockingHttpConnection.handle(BlockingHttpConnection.java:66)
at org.seleniumhq.jetty7.server.bio.SocketConnector$ConnectorEndPoint.run(SocketConnector.java:254)
at org.seleniumhq.jetty7.util.thread.QueuedThreadPool.runJob(QueuedThreadPool.java:599)
at org.seleniumhq.jetty7.util.thread.QueuedThreadPool$3.run(QueuedThreadPool.java:534)
at java.lang.Thread.run(Thread.java:745)

Selenium version: 2.47.1
Browser: Google Chrome 46.0.2490.86
Chrome driver version: 2.20

Selenium grid node configuration is:
{
"capabilities":
[
{
"browserName": chrome,
"maxInstances": 5,
"extension.sikuliCapability": True
} ],
"configuration": {
"host":<redacted>,
"port":5555,
"cleanUpCycle":2000,
"timeout":30000,
"register": True,
"registerCycle": 5000,
"browserTimeout":60000,
"hubHost":<redacted>
"hubPort":4444,
"proxy":"org.openqa.grid.selenium.proxy.DefaultRemoteProxy",
"maxSession":5,
"registerCycle":5000,
"nodePolling":2000,
"unregisterIfStillDownAfter":60000,
"downPollingLimit":10,
"nodeStatusCheckTimeout":10000,
"servlets":"com.ericsson.taf.selenium.node.sikuli.SikuliExtensionServlet,com.ericsson.taf.selenium.node.upload.FileUploadServlet,com.ericsson.taf.selenium.node.download.FileDownloadServlet"
}
}

We need help to fix this issue, so if anyone get idea about this issue, please leave a comment.
Thanks very much.

Zhao