Let $A_n$ denote the set of noncrossing fixed point free involutions in the symmetric group $S_{2n}$. "Noncrossing" means that if $a<b<c<d$, then not both $(a,c)$ and $(b,d)$ can be cycles of $w\in A_n$. The cardinality of $A_n$ is the Catalan number $C_n =\frac{1}{n+1}{2n\choose n}$. A meander of order $n$ may be defined as a pair $(u,v)\in A_n\times A_n$ such that $uv$ has exactly two cycles (necessarily of length $n$). Let $\kappa(w)$ denote the number of cycles of the permutation $w$. The meander matrix $\mathcal{G}_{2n}(q)$ is the matrix whose rows and columns are indexed by elements of $A_n$, with $(\mathcal{G}_{2n}(q))_{u,v}$ equal to $q^{\kappa(uv)/2}$. Di Francesco has shown here that $$ \det \mathcal{G}_{2n}(q) =\prod_{m=1}^n U_m(q)^{a_{2n,2m}}, $$ where $U_m(q)$ is a Chebyshev polynomial of the second kind, and $a_{2n,2m}$ is a certain nonnegative integer. (Note: Di Francesco defines $U_m(2\cos\theta)=\frac{\sin(m+1)\theta}{\sin\theta}$, while I think it is more traditional to define $U_m(\cos\theta)=\frac{\sin(m+1)\theta}{\sin\theta}$.)
What if we refine the definition of $\mathcal{G}_{2n}(q)$ by defining $(\mathcal{H}_{2n})_{u,v}$ to be $\prod_i p_i^{\lambda_i}$, where $uv$ has $2\lambda_i$ cycles of length $i$? Here $p_i=\sum_j x_j^i$, the $i$th power sum symmetric function. Then for instance, $$ \det \mathcal{H}_6 = (p_1^3-p_3)^3 (p_1^6+3p_1^3 p_3 -6p_1^2p_2^2 +2p_3^2). $$ We don't get as much factorization as for $\mathcal{G}_6(q)$, but we do get some factorization. I was unable to compute $\det\mathcal{H}_8$.
It is also true that the irreducible factors of $\det \mathcal{H}_6$ are Schur positive, i.e., nonnegative linear combinations of the Schur functions $s_\lambda$. Does this property persist for all $n$?
The sum of the entries of $\mathcal{G}_{2n}(q)$ gives the enumeration of pairs $(u,v)\in A_n\times A_n$ by half the number of cycles of $uv$. For $n=3$ this is $5q^3+12q^2+8q$. What can be said about the sum of the entries of $\mathcal{H}_{2n}$? I have checked that it is Schur positive for $n\leq 6$.
My last question is only peripherally related to meanders. Let $R_n = \sum_{w\in A_n} w\in \mathbb{Q}S_{2n}$, where $\mathbb{Q}S_{2n}$ denotes the group algebra of $S_{2n}$ over $\mathbb{Q}$. What can be said about $R_n$? For instance, its eigenvalues (when acting by left multiplication on $\mathbb{Q}S_{2n}$), its mixing time (i.e., what is the least $k$ (asymptotically) for which $(R_n/C_n)^k$ is approximately the uniform distribution on the set of even or of odd permutations in $S_{2n}$ (whichever is appropriate)), etc? If all eigenvalues of $R_n^2$ are real and nonnegative, then can we modify the answer of Brendan Pawlowski at MO254782 to conclude that the sum of the entries of $\mathcal{H}_{2n}$ is Schur positive?
Addendum. I computed $\det\mathcal{H}_8$. (It was almost instantaneous on my home PC. I don't know why it failed on an MIT Math. Dept. server.) It factors as $a\cdot b\cdot c^2 \cdot d^2$, where $a,b,c,d$ are irreducible homogeneous symmetric functions of degrees $12, 12, 8, 8$, respectively. Each of $a,b,c,d$ is Schur positive.
Addendum2. Let $\mathrm{scp}_{2n} = \det(\mathcal{H}_{2n}+I_{2n}x)$, essentially the characteristic polynomial of $\mathcal{H}_{2n}$. I computed $\mathrm{scp}_6$ and $\mathrm{scp}_8$. It seems remarkable to me that they factor in the same way as the determinant (the case $x=0$). Moreover, for any $j$ the coefficient of $x^j$ in $\mathrm{scp}_6$ and $\mathrm{scp}_8$ is Schur positive. For $\det(\mathcal{G}_6(q)+I_6x)$, the factorization follows that of $\mathcal{H}_6$ (not $\mathcal{G}_6(q)$). For $\det(\mathcal{G}_8(q)+I_8x)$, the factorization follows that of $\mathcal{H}_8$ except that the two factors of degree 12 and multiplicity two merge into a single factor of multiplicity four.