The work of Street "Two-dimensional sheaf theory" (JPAA 23 1982 251-270) is relevant I believe.
He has notions of 1-separated and 2-separated, and a 2-analog of the $\_^+$ functor which he calls $L$, with natural transformation $l:\text{identity}\to L$, such that
- $P$ is 1-separated iff $l_P:P\to LP$ is mono;
- for every $P$, $LP$ is 1-separated;
- $P$ is 2-separated iff $l_P:P\to LP$ is $\textit{chronic}$;
- for every 1-separated $P$, $LP$ is 2-separated;
- $P$ is a stack iff $l_P:P\to LP$ is an isomorphism;
- for every 2-separated $P$, $LP$ is a stack.
Here a morphism $f:P\to Q$ is called chronic when the functor $\hom(X,f):\hom(X,P)\to\hom(X,Q)$ is full, faithful and injective on objects for every $X$.
Comparing this with the properties of $\_^+$ seemingly leads to the conclusion that separatedness naturally splits into two notions, something like "$2/3$-separatedness" and "$4/3$-separatedness".
See also the (later) Question regarding 2-mathematics: Can you stackify a 2-functor without prestackifying it first?Question regarding 2-mathematics: Can you stackify a 2-functor without prestackifying it first? here on MO.
Update
After comments by David Roberts I must confess I no longer believe it is relevant. However I still don't understand why it is irrelevant, so let me leave it for a while. Sorry.