The distutils upload command creates a MD5 digest of the file content. This is not compatible with systems with systems that run under a strict security policy that blocks MD5. Possible fixes are: * declare that the MD5 digest is not used for security. Security is provided by TLS/SSL and HTTPS. The digest is just a simple checksum to detect file corruption during upload. * Remove MD5 digest completely * Don't create a MD5 digest if ``hashlib.md5(content)`` fails * Skip the test case if MD5 is not available Does PyPI support other digests, e.g. SHA2-256 digest?