Currently a list of constants is replaced with constant tuple in `x in [1, 2]` and `for x in [1, 2]`. The resulted AST is the same as for `x in (1, 2)` and `for x in (1, 2)`. The proposed simple PR extends this optimization to lists containing non-constants. `x in [a, b]` will be changed into `x in (a, b)` and `for x in [a, b]` will be changed into `for x in (a, b)`. Since creating a tuple is faster than creating a list the latter form is a tiny bit faster. $ ./python -m timeit -s 'a, b = 1, 2' -- 'for x in [a, b]: pass' 5000000 loops, best of 5: 93.6 nsec per loop $ ./python -m timeit -s 'a, b = 1, 2' -- 'for x in (a, b): pass' 5000000 loops, best of 5: 74.3 nsec per loop ./python -m timeit -s 'a, b = 1, 2' -- '1 in [a, b]' 5000000 loops, best of 5: 58.9 nsec per loop $ ./python -m timeit -s 'a, b = 1, 2' -- '1 in (a, b)' 10000000 loops, best of 5: 39.3 nsec per loop