maybe I miss something but I have downloaded the last fedora:rawhide with docker, just update it via dnf update and install all the dependencies for git and python docker --rm -it fedora:rawhide /bin/bash dnf update dnf install git-core dnf builddep python3 git clone --depth=1 https://github.com/python/cpython cd cpython ./configure && make and I have no issue with ctypes. What are your instructions for the build? Thank you