A think tank for accelerating scientific, technological, and industrial progress
Policy research and strategy to remove the bottlenecks to US growth
Over the last 50 years, our rate of innovation has been slowing down while the global challenges we face have been growing. To combat climate change, future pandemics, and economic stagnation, we need to leverage the United States' unique advantages and chart a path to abundance.
Metascience
How can we change the incentives within science to produce more breakthrough research?
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High-Skilled Immigration
How can we attract and retain superstar talent from around the globe?
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Biotechnology
How can we prevent future pandemics and accelerate progress in the life sciences?
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Infrastructure
How can we make it easier to build things in the world of atoms?
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Emerging Technology
How can we shape the frontier of technological development and deployment?
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Spotlight research
High-Skilled Immigration
The “Wage Level” Mirage
How DHS’s H-1B proposal could help outsourcers and hurt US-trained talent
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Emerging Technology
Preparing for Launch
An introduction to The Launch Sequence: Why shaping AI progress matters, and how to go about it
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Metascience
Indirect Cost Recovery and American Innovation: Context and Ideas for Reform
How the government covers indirect costs directly affects scientific innovation
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Emerging Technology
Catalyzing a Golden Age: A Blueprint for Strategic AI R&D Investment
Response to the OSTP RFI on the Development of a 2025 National AI R&D Strategic Plan
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Read more recent publications
Emerging Technology
Unlocking a Million Times More Data for AI
How a new ARPANET-style program could solve the data accessibility problem
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Metascience
American Science Should Take a Lot More Risks
Scientific efficiency isn’t primarily about the dollars we could save; it’s about the breakthroughs we could be missing
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Emerging Technology
Teaching AI How Science Actually Works
How block-grant labs can generate the real-world data AI needs to do science
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Emerging Technology
Using X-Labs to Unleash AI-Driven Scientific Breakthroughs
How to adapt our science funding mechanisms to the unique infrastructure needs of large-scale AI projects
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Emerging Technology
The Replication Engine
How to build automated replication infrastructure for better, faster science
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Emerging Technology
Benchmarking for Breakthroughs
How to incentivize AI for national priorities through a strategic challenge and evaluations program
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Emerging Technology
Scaling Materials Discovery with Self-Driving Labs
How to close the gap between AI-guided material design and real-world validation
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Emerging Technology
A Million-Peptide Database to Defeat Antibiotic Resistance
How to build a large peptides database to train the AlphaFold for new antibiotics
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Emerging Technology
Faster AI Diffusion Through Hardware-Based Verification
How to use privacy-preserving verification in the AI hardware stack to build trust and limit misuse
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Emerging Technology
Operation Patchlight
How to leverage advanced AI to give defenders an asymmetric advantage in cybersecurity
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Emerging Technology
A Sprint Toward Security Level 5
How to protect American AI from nation-state level threats
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Emerging Technology
Preventing AI Sleeper Agents
How to ensure American AI models are robust and reliable via a DOD-led red- and blue-teaming effort
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