index = pd.Index([23, 26, 30]) dti = pd.DatetimeIndex(['2015-09-23', '2015-09-26', '2015-09-30']) ser = pd.Series(dti, index=index).reindex(range(23, 31)) df = pd.DataFrame(ser) >>> ser # for reference 23 2015-09-23 24 NaT 25 NaT 26 2015-09-26 27 NaT 28 NaT 29 NaT 30 2015-09-30 dtype: datetime64[ns] >>> ser.interpolate() 23 2015-09-23 24 NaT 25 NaT 26 2015-09-26 27 NaT 28 NaT 29 NaT 30 2015-09-30 dtype: datetime64[ns] >>> df.interpolate() 0 23 2015-09-23 24 NaT 25 NaT 26 2015-09-26 27 NaT 28 NaT 29 NaT 30 2015-09-30 

index = pd.Index([23, 26, 30]) dti = pd.DatetimeIndex(['2015-09-23', '2015-09-26', '2015-09-30'], tz='US/Central') ser = pd.Series(dti, index=index).reindex(range(23, 31)) df = pd.DataFrame(ser) >>> ser 23 2015-09-23 00:00:00-05:00 24 NaT 25 NaT 26 2015-09-26 00:00:00-05:00 27 NaT 28 NaT 29 NaT 30 2015-09-30 00:00:00-05:00 dtype: datetime64[ns, US/Central] >>> ser.interpolate() 23 2015-09-23 00:00:00-05:00 24 NaT 25 NaT 26 2015-09-26 00:00:00-05:00 27 NaT 28 NaT 29 NaT 30 2015-09-30 00:00:00-05:00 dtype: datetime64[ns, US/Central] >>> df.interpolate() Traceback (most recent call last): File "<stdin>", line 1, in <module> File "/usr/local/lib/python2.7/site-packages/pandas/core/generic.py", line 4738, in interpolate 'object') == len(_maybe_transposed_self.T): File "/usr/local/lib/python2.7/site-packages/pandas/core/frame.py", line 1909, in transpose return super(DataFrame, self).transpose(1, 0, **kwargs) File "/usr/local/lib/python2.7/site-packages/pandas/core/generic.py", line 599, in transpose new_values = self.values.transpose(axes_numbers) File "/usr/local/lib/python2.7/site-packages/pandas/core/base.py", line 696, in transpose nv.validate_transpose(args, kwargs) File "/usr/local/lib/python2.7/site-packages/pandas/compat/numpy/function.py", line 54, in __call__ self.defaults) File "/usr/local/lib/python2.7/site-packages/pandas/util/_validators.py", line 218, in validate_args_and_kwargs validate_kwargs(fname, kwargs, compat_args) File "/usr/local/lib/python2.7/site-packages/pandas/util/_validators.py", line 157, in validate_kwargs _check_for_default_values(fname, kwds, compat_args) File "/usr/local/lib/python2.7/site-packages/pandas/util/_validators.py", line 69, in _check_for_default_values format(fname=fname, arg=key))) ValueError: the 'axes' parameter is not supported in the pandas implementation of transpose()